A-72363 A-1, A-2, and C, Novel Heparanase Inhibitors from Streptomyces nobilis SANK 60192 I. Taxonomy of Producing Organism, Fermentation, Isolation, and Structure Elucidation

TOSHIO TAKATSU; MASAAKI TAKAHASHI; YUMI KAWASE; RYUZO ENOKITA; TAKAO OKAZAKI; HIROSHI MATSUKAWA; KANEO OGAWA; YOSHIHARU SAKAIDA; TAKESHI KAGASAKI; TAKESHI KINOSHITA; MOTOWO NAKAJIMA; KAZUHIKO TANZAWA

doi:10.7164/antibiotics.49.54

A-72363 A-1, A-2, and C, Novel Heparanase Inhibitors from Streptomyces nobilis SANK 60192

I. Taxonomy of Producing Organism, Fermentation, Isolation, and Structure Elucidation

TOSHIO TAKATSU, MASAAKI TAKAHASHI, YUMI KAWASE, RYUZO ENOKITA, TAKAO OKAZAKI, HIROSHI MATSUKAWA, KANEO OGAWA, YOSHIHARU SAKAIDA, TAKESHI KAGASAKI, TAKESHI KINOSHITA, MOTOWO NAKAJIMA, KAZUHIKO TANZAWA

Author information

TOSHIO TAKATSU
Biomedical Research Laboratories, Sankyo Co., Ltd.
MASAAKI TAKAHASHI
Biological Research Laboratories, Sankyo Co., Ltd.
YUMI KAWASE
Biological Research Laboratories, Sankyo Co., Ltd.
RYUZO ENOKITA
Tsukuba Research Laboratories, Sankyo Co., Ltd.
TAKAO OKAZAKI
Tsukuba Research Laboratories, Sankyo Co., Ltd.
HIROSHI MATSUKAWA
Biomedical Research Laboratories, Sankyo Co., Ltd.
KANEO OGAWA
Biomedical Research Laboratories, Sankyo Co., Ltd.
YOSHIHARU SAKAIDA
Biomedical Research Laboratories, Sankyo Co., Ltd.
TAKESHI KAGASAKI
Biomedical Research Laboratories, Sankyo Co., Ltd.
TAKESHI KINOSHITA
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
MOTOWO NAKAJIMA
Institute of molecular and Cellular Biosciences, The University of Tokyo
KAZUHIKO TANZAWA
Biological Research Laboratories, Sankyo Co., Ltd.

JOURNAL FREE ACCESS

1996 Volume 49 Issue 1 Pages 54-60

DOI https://doi.org/10.7164/antibiotics.49.54

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Abstract

Novel heparanase inhibitors, A-72363 A-1, A-2, and C, were isolated from the culture filtrate of Streptomyces nobilis SANK 60192 by column chromatography on various resinous adsorbents, followed by preparative anion exchange HPLC. Spectroscopic studies revealed that they are diastereomers of siastatin B, a neuraminidase inhibitor.

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