Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule II. Physicochemical Properties and Structural Elucidation

SATOSHI TAKAMATSU; YONG-PIL KIM; MASAHIKO HAYASHI; HIDEMI HIRAOKA; MASAHIKO NATORI; KANKI KOMIYAMA; SATOSHI OMURA

doi:10.7164/antibiotics.49.95

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule

II. Physicochemical Properties and Structural Elucidation

SATOSHI TAKAMATSU, YONG-PIL KIM, MASAHIKO HAYASHI, HIDEMI HIRAOKA, MASAHIKO NATORI, KANKI KOMIYAMA, SATOSHI OMURA

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 1 Pages 95-98

DOI https://doi.org/10.7164/antibiotics.49.95

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Abstract

New anticell-adherence compounds, macrosphelides A and B, were isolated from the fermentation broth of Microsphaeropsis sp. FO-5050, and their structures were elucidated by spectroscopic methods and by chemical transformations. Macrosphelides A (M.W. 342, C₁₆H₂₂O₈) and B (M.W. 340, C16H₂₀O₈) with three esters in their molecules were classified as 16-membered macrocyclic compounds. Macrosphelide B was found to be a corresponding oxidative product of macrosphelide A at the C-14 position.

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