TOP > Available Issues > Table of Contents > Abstract
| | ONLINE | ISSN | : | 1347-6947 | | PRINT | ISSN | : | 0916-8451 |
|
| | Bioscience, Biotechnology, and Biochemistry |
| Vol. 65 (2001) , No. 2 pp.452-455 |
| [Image PDF (775K)] [References]  |
 | Inhibitory Activity of Berberine on DNA Strand Cleavage Induced by Hydrogen Peroxide and Cytochrome c
|
| | 1) Division of Bioscience and Biotechnology, Woosuk University
2) Division of Food Science and Technology, Woosuk University |
| (Received August 9, 2000)
(Accepted September 29, 2000)
|
| | The inhibitory activity of berberine on the DNA single-strand cleavage induced by hydrogen peroxide and cytochrome c was measured. Berberine effectively inhibited single-strand cleavage of DNA and its effectiveness was concentration-dependent. As the berberine concentration increased, the inhibitory activity against the DNA single-strand cleavage increased. The treatments with 1,5,10,50, and 100 μM berberine showed 7.7,10.8,32.2,39.5, and 51.6% inhibition of DNA cleavage. This inhibitory activity of berberine against the DNA single-strand cleavage has never been reported previously. The inhibitory activity of berberine against DNA cleavage was stronger than caffeic acid and ascorbic acid. Berberine did not show strong hydroxyl radical scavenging activity, but showed strong superoxide anion radical quenching ability. |
| | | |
| To cite this article: | | Dong-Seong CHOI, Sang-Jin KIM and Mun Yhung JUNG, “Inhibitory Activity of Berberine on DNA Strand Cleavage Induced by Hydrogen Peroxide and Cytochrome c”, Biosci. Biotechnol. Biochem., Vol. 65, 452-455 (2001) . | |
|
| doi:10.1271/bbb.65.452 | | JOI JST.JSTAGE/bbb/65.452 |
| Copyright (c) 2001 by Japan Society for Bioscience, Biotechnology, and Agrochemistry |
|
|
