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| | ONLINE | ISSN | : | 1347-5215 | | PRINT | ISSN | : | 0918-6158 |
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| | Biological & Pharmaceutical Bulletin |
| Vol. 30 (2007) , No. 9 1624 |
| [PDF (239K)] [References]  |
 | PTEN: Its Deregulation and Tumorigenesis
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| | | 1) Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases |
| (Received February 27, 2007)
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| | The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of upstream regulatory factors for PTEN and unveiled that the impairment in the PTEN regulatory system potentially becomes a causal factor for oncogenic transformation of cells. This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators. |
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| To cite this article: | | Tomohiko Maehama, “PTEN: Its Deregulation and Tumorigenesis”, Biol. Pharm. Bull., Vol. 30, 1624-1627 (2007) . | |
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| doi:10.1248/bpb.30.1624 | | JOI JST.JSTAGE/bpb/30.1624 |
| (c) 2007 The Pharmaceutical Society of Japan |
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