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Circulation Journal
Vol. 66 (2002) , No. 12 1181-1184
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Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy)
Three Cases

Michifumi Kyuma1), Kazufumi Tsuchihashi1), Yasuyuki Shinshi1), Mamoru Hase1), Tomoaki Nakata1), Hitoshi Ooiwa2), Masayoshi Abiru2), Nobuichi Hikita3), Tateo Adachi3), Tetsuro Shoji3), Yukiyasu Fujise2) and Kazuaki Shimamoto1)
1) Second Department of Internal Medicine, Sapporo Medical University School of Medicine
2) Division of Cardiovascular Medicine, Oji General Hospital, Tomakomai
3) Division of Cardiovascular Medicine, Muroran City General Hospital, Muroran
(Received October 29, 2001)
(Revised manuscript received January 7, 2002)
(Accepted January 17, 2002)

The precise etiological basis of transient left ventricular apical ballooning without coronary artery stenosis (ampulla or so-called `takotsubo' cardiomyopathy) remains unknown, so the present study examined the acute effects of intravenous propranolol (2-4 mg) in 3 female patients (age range, 61-76 years) with the condition. Although one patient who did not have any intraventricular pressure gradients showed no improvement in the electrocardiographic and left ventricular wall motion abnormalities, the other 2 patients, who had significant intraventricular pressure gradients, did show improvement. Dynamic intraventricular obstruction might play a role in maintaining apical ballooning, at least, in patients exhibiting an intraventricular pressure gradient. (Circ J 2002; 66: 1181 - 1184)
Key Words:Ampulla cardiomyopathy; Propranolol; Regional apical ballooning; Takotsubo cardiomyopathy

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To cite this article:
Michifumi Kyuma, Kazufumi Tsuchihashi, Yasuyuki Shinshi, Mamoru Hase, Tomoaki Nakata, Hitoshi Ooiwa, Masayoshi Abiru, Nobuichi Hikita, Tateo Adachi, Tetsuro Shoji, Yukiyasu Fujise and Kazuaki Shimamoto “Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy)”; Circ J. Vol. 66. 1181-1184. (2002) .

doi:10.1253/circj.66.1181
JOI  JST.JSTAGE/circj/66.1181
Copyright (c) 2002 THE JAPANESE CIRCULATION SOCIETY



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