Supported by the fact that N-methyl-N-2-chloroethyl-3-chloropropylamine exhibited a strong antitumor effect on Yoshida sarcoma or series of rat ascites hepatomas, eight derivatives of nitrogen mustard were newly synthesized, which have only one but highly reactive 2-chloroethyl group in a molecule. Antitumor test of these compounds on Yoshida sarcoma was, however, negative.
