Available Issues  |  Japanese>>  Publisher Site  
Author: ADVANCED
Keyword:
Volume Page
            My J-STAGE HELP
 
TOP > Available Issues > Table of Contents > Abstract

PRINTISSN:0021-521X
The Japanese Journal of Physiology
Vol. 55 (2005) , No. 6 339-344
[PDF (651K)] [References] [Citing Articles] 

Analgesic Effect of Electroacupuncture on Complete Freund's Adjuvant-Induced Inflammatory Pain in Mice: A Model of Antipain Treatment by Acupuncture in Mice
W.M. Li1)2), K.M. Cui1), N. Li1), Q.B. Gu2), W. Schwarz2), G.H. Ding2)3) and G.C. Wu1)
1) Department of Integrative Medicine, Shanghai Medical College, Fudan University
2) Shanghai Research Center of Acupuncture and Meridian
3) Department of Mechanics and Engineering Science, Fudan University
(Received November 20, 2005)
(Accepted December 12, 2005)
Abstract:  Electroacupuncture (EA) was applied bilaterally to the acupoints of Zu-san-li (ST-36) and Kun-lun (BL-60) in the hindlimbs of mice. The therapeutic effect of EA on inflammatory pain induced by an ipsilateral injection of complete Freund's adjuvant (CFA) into the right paw of the mouse was investigated in this study. The time of paw-withdrawal latency (PWL) was used as an indicator for judging the intensity of the pain induced by the CFA injection. The EA effects were divided into immediate (PWL tests within 2 h after EA treatment) and cumulative (PWL tests during and after repetitive EA treatments for 3 weeks) effects. As immediate effects, PWL was significantly shortened in the CFA-injected paw, but was again prolonged 20 min after an EA treatment and lasted until 30 min after. As cumulative effects, PWL was significantly shortened in the CFA-injected paw, but recovered from the 2nd to the 8th day during repetitive EA treatments. No such effects could be observed after sham EA treatment, which resulted in behavior similar to that in untreated animals. These results demonstrate that the CFA-induced inflammatory pain in mice is an ideal model system for the investigation of EA effects and may serve as a valuable reference for the clinical treatment of inflammatory pain in human beings. Furthermore, the mouse pain model opens the possibility to apply the investigation also to transgenic mice.
Key words:  electroacupuncture, acupoint, inflammatory pain, complete Freund's adjuvant, paw-withdrawal latency

[PDF (651K)] [References] [Citing Articles] 
Download Meta of Article[Help]
RIS
BibTeX

To cite this article:
W.M. Li, K.M. Cui, N. Li, Q.B. Gu, W. Schwarz, G.H. Ding and G.C. Wu: “Analgesic Effect of Electroacupuncture on Complete Freund's Adjuvant-Induced Inflammatory Pain in Mice: A Model of Antipain Treatment by Acupuncture in Mice”, JJP Vol. 55: 339-344, (2005) .
doi:10.2170/jjphysiol.RP001505
JOI  JST.JSTAGE/jjphysiol/RP001505
Copyright (c) 2006 by The Physiological Society of Japan
View "Advance Publication" version (December 17, 2005).

Japan Science and Technology Information Aggregator, ElectronicJ-STAGE