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| | ONLINE | ISSN | : | 1347-7439 | | PRINT | ISSN | : | 0916-7250 |
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| | Journal of Veterinary Medical Science |
| Vol. 66 (2004) , No. 6 June pp.739-741 |
| [PDF (61K)] [References]  |
 | Molecular Cloning of Canine Activation-Induced Cytidine Deaminase (AID) cDNA and Its Expression in Normal Tissues
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| | | 1) Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo |
| (Received 31-Oct-2003)
(Accepted 19-Jan-2004)
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| ABSTRACT. Activation-induced cytidine deaminase (AID) is essential for class switch recombination, somatic hypermutation, and gene conversion of immunoglobulin gene. In the present study, canine AID cDNA was cloned from the lymph node of a healthy dog by RT-PCR with rapid amplification of cDNA ends (RACE) method. The canine AID cDNA was 1,377 bp in length, and contained the entire open reading frame encoding 198 amino acids which had 94.9%, 94.4%, and 89.9% homology with human, mouse, and chicken homologues, respectively. Canine AID mRNA was expressed in thymus, lung, spleen, kidney, small intestine, lymph node, and tonsil of a healthy dog, similar to humans.
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| To cite this article: | | Keitaro OHMORI, Sadatoshi MAEDA, Taro OKAYAMA, Kenichi MASUDA, Koichi OHNO and Hajime TSUJIMOTO “Molecular Cloning of Canine Activation-Induced Cytidine Deaminase (AID) cDNA and Its Expression in Normal Tissues”. J. Vet. Med. Sci.. Vol. 66: 739-741. (2004) . | |
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| doi:10.1292/jvms.66.739 | | JOI JST.JSTAGE/jvms/66.739 |
| Copyright(c) 2004 by the Japanese Society of Veterinary Science |
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