Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 47, Issue 6
Displaying 1-8 of 8 articles from this issue
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Original Articles
  • Discrimination between acute hepatitis B and acute exacerbations of chronic hepatitis B by measurement of IgM class antibody to hepatitis B core antigen by CLIA method
    Rumiko Nakao, Hiroshi Yatsuhashi, Masashi Myoji, Takahiko Tsuchida, Ko ...
    Article type: Original Article
    2006 Volume 47 Issue 6 Pages 279-282
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.279
    JOURNAL FREE ACCESS
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    To determine the diagnostics value of IgM class antibody to hepatitis B core antigen (anti-HBc IgM) among patients with acute hepatitis B (AH-B) and acute exacerbation of chronic hepatitis B (CH-Be), the sera from 53 patients with known AH-B and 60 patients with known CH-Be were studied for anti-HBc IgM by Chemiluminescent Immunoassay (CLIA). The anti-HBc IgM titer level greater than 10.0S/CO was 92% in AH-B and 7% in CH-Be, with better accuracy 93% (105/113) comparing to qualitative cutoff levels accuracy 68% (77/113).
    As a consequence, only using just "positive" or "negative" results of anti-HBc IgM detection is not enough to distinguish both AH-B and CH-Be.
    According to the results from the study, we found that it is useful for differentiating between AH-B and CH-Be, with the titer of anti-HBc IgM greater than or below 10.0S/CO.
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  • Efficacy of radiation therapy for advanced hepatocellular carcinoma with vascular and/or bile duct involvement
    Yosuke Horita, Hidero Ogino, Katsushi Hiramatsu, Mitsuru Matsuda, Yosh ...
    Article type: Original Article
    2006 Volume 47 Issue 6 Pages 283-289
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.283
    JOURNAL FREE ACCESS
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    The aim this study was to evaluate the efficacy of radiation therapy (RT) for unresectable hepatocellular carcinoma (HCC) with vascular and/or bile duct involvement. From April 1996 to March 2002, 21 patients who were treated with RT in our hospital were evaluated. In all patients, RT was well tolerated and completed as planned. The radiation dose was 30.1∼61.6Gy (mean; 47.2Gy) with 1.8∼2.0Gy as a daily dose. The tumor response was evaluated by the measurement of the size on CT scan and the mean survival time was calculated with the use of Kaplan-Meier analysis and compared with the use of the log-rank test. As a result, the minor response (MR) or better was observed 5 in 21 patients (23.8%) and the mean survival time after RT was 242 days (25-949 days). In conclusion, RT may demonstrate the tumor response with minimal toxicity in some patients with advanced HCC with vascular and/or bile duct involvement.
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  • Analysis including gene polymorphism in non-responder to interferon and ribavirin combined therapy
    Noriko Matsushita, Katsutoshi Tokushige, Mihoko Takakura, Maki Tobari, ...
    Article type: Original Article
    2006 Volume 47 Issue 6 Pages 290-297
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.290
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    Factors influencing the efficacy of IFN and ribavirin therapy were not clear. We investigated gene polymorphisms of non-responders (NR).
    (Patients) Sixty-six chronic hepatitis patients with HCV received the combined therapy of IFN and ribavirin. Gene polymorphisms of IL-10 promoter region, MxA promoter region, TNF-α promoter region and TNF-β Nco1 site were studied.
    (Results) In patients with serotype 2, NR was significantly decreased, compared to transient responders (TR) or sustained responders (SR). The amount of HCV was not associated with the effectiveness. The frequency of severe fibrosis in NR was higher than that in TR and SR. There was no association of gene polymorphisms with IL-10 promoter region, MxA promoter region or TNF-α promoter region. In TNF-β gene polymorphism, B2/B2 frequency was significantly increased in NR, compared with TR and SR.
    (Conclusion) Serotype, liver fibrosis and TNF-β gene polymorphism might be associated with non-responders to the combined therapy.
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Case Reports
  • Two cases of hepatitis-associated aplastic anemia
    Takashi Goto, Hiroki Ishikawa, Akira Saeki, Naruhiko Ikari, Mariko Fuk ...
    Article type: Case Report
    2006 Volume 47 Issue 6 Pages 298-303
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.298
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    We experienced two cases of hepatitis-associated aplastic anemia. First case was a 35-years-old man who has developed cryptogenic hepatitis in April 2003. Although his liver function was normalized in July, pancytopenia began to develop gradually. Second case was a 26-years-old man who has developed cryptogenic hepatitis in June 2003. After admission, his liver dysfunction was gradually improved. However, two weeks later, pancytopenia was suddenly appeared. Both cases were diagnosed as hepatitis-associated aplastic anemia on the basis of liver dysfunction, pancytopenia and hypocellular bone marrow. Immunosuppressive therapy was effective for pancytepenia in both cases. We should pay attention to aplastic anemia associated with cryptgenic hepatitis especially at young age.
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  • A case of PBC-AIH overlap syndrome deteriorated autoimmune hepatitis during the administration of ursodeoxycholic acid
    Kohichi Takada, Junji Kato, Kunihiro Takanashi, Yutaka Kawano, Toshino ...
    Article type: Case Report
    2006 Volume 47 Issue 6 Pages 304-309
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.304
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    A 54-year-old woman diagnosed as PBC-AIH overlap syndrome had been treated with UDCA. She was admitted to our hospital due to acute exacerbation of serum transaminase levels on January, 2004. Serum IgG level was normal, but liver biopsy showed worsened AIH. Human leukocyte antigen (HLA) DR4 was positive. According to the IAHG scoring system, her score was 11 points, indicating probable AIH. The serum transaminase levels effectively decreased after administration of corticosteroid. It is suggested that HLA DR4-positive patients with PBC-AIH overlap syndrome may develop worsened AIH during UDCA treatment.
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  • A juvenile female case of liver cirrhosis found by the chance of an oral administration of turmeric
    Taira Zenitani, Masaru Takagi, Takashi Araki, Masashi Takamatsu, Kenji ...
    Article type: Case Report
    2006 Volume 47 Issue 6 Pages 310-315
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.310
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    A 18 year-old female, who has been health, developed jaundice and liver injury during oral administrating of turmeric and hormonal agents. Cirrhosis with plasma cell infiltrations, Rossets formation and marked hemorrhagic necrosis were observed in liver biopsy specimens. Splenomegaly and gastrorenal shunt of abdominal computed tomography and esophagogastiric varices of endoscopic findings were visualized. International diagnostic criteria score of autoimmune hepatitis (AIH) was probale (+15 points before treatment). Porto-systemic shunt was found and AIH has been considered to preexist for long time.
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Short Communication
  • Detection of hepatitis E virus (HEV) and sero prevalence of HEV in wild animals and hunters families
    Miyabi Ito, Shinichi Kobayashi, Teruo Yamashita, Akiko Hasegawa, Kenji ...
    Article type: Short Communication
    2006 Volume 47 Issue 6 Pages 316-318
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.316
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    Sporadic cases of hepatitis E have been reported in developed countries including Japan. The source of HEV in many cases is unknown, although zoonotic transmission has been suggested. In this study, HEV strains detected from wild boars have been characterized by RT-PCR and sequencing and an antibody to HEV has been measured in Japanese wild boars and hunters families. Of the 91-wild boars, 25 strains were seropositive for HEV, and eleven were positive for HEV-RNA. Sequencing analysis showed that HEV detected from wild boars in Aichi belong to genotype IV cluster. These results indicate that HEV is widespread in the wild boar of this area and that wild boar may serve as reservoirs for HEV infection.
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Rapid Communication
  • Atypical length of the TRIF polyproline track possibly associated with spontaneous clearance of HCV RNA
    Michie Hashimoto, Masahiro Arai, Shunji Mishiro
    Article type: Rapid Communication
    2006 Volume 47 Issue 6 Pages 319
    Published: 2006
    Released on J-STAGE: November 28, 2006
    DOIhttps://doi.org/10.2957/kanzo.47.319
    JOURNAL FREE ACCESS
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    We questioned whether there might be certain people who have TRIF that cannot be cut by HCV NS3/4A protease. Although the cleavage motif was invariably SSTPC/SAHLTPSSLE in all the 62 Japanese subjects examined, we found a genetic polymorphism at the polyproline track just upstream of the cleavage motif of TRIF: that is, the repeat number of proline was 8 in majority, but it was 6 or 9 in occasional subjects. Interestingly, the variant type TRIF (with 6 or 9 prolines) was found only in 13% (5/40) of those persistently infected with HCV, whereas it was found in 41% (9/22) of those who were positive for anti-HCV but negative for HCV RNA.
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