A large response to ground motion was predicted in a seismically isolated building at a near-fault location. The response distribution of isolated buildings was estimated by utilizing the disclosed ground motion records from the 2016 Kumamoto earthquake, as observed by K-NET and KiK-net. The results showed the existence of a limited local area near the end of a fault rupture where severe displacements occurred in the seismic isolators. The area was near the end of a fault rupture. The observed displacement of the isolators of the actual buildings agreed with these estimated values.