A cerebral thrombus or blood clot might cause cerebral stroke and even decease if the clot could not be dissolved within several hours after it was formed. This paper presents a fundamental study on the development of a new type of mechanical micro stirrer for assisting the dissolution of the thrombus with a few amount of thrombolytic agent. The micro stirrer is made of a slight beam embedded with a piezocell. To evaluate the dissolution state in vivo, the method using the piezo-stirrer as the probe to evaluate its solubility is proposed. An efficient excitation method for stirring up the thrombus to get a quick dissolution was investigated. The potential of the piezo-stirrer has been validated experimentally.