ANTIBIOTICS FROM BASIDIOMYCETES XXXVII. NEW INHIBITORS OF CHOLESTEROL BIOSYNTHESIS FROM CULTURES OF <i>XERULA MELANOTRICHA</i> DÖRFELT

DOROTHÉE KUHNT; TIMM ANKE; HELMUT BESL; MONIKA BROSS; RUPERT HERRMANN; URSULA MOCEK; BERT STEFFAN; WOLFGANG STEGLICH

doi:10.7164/antibiotics.43.1413

ANTIBIOTICS FROM BASIDIOMYCETES

XXXVII. NEW INHIBITORS OF CHOLESTEROL BIOSYNTHESIS FROM CULTURES OF XERULA MELANOTRICHA DÖRFELT

DOROTHÉE KUHNT, TIMM ANKE, HELMUT BESL, MONIKA BROSS, RUPERT HERRMANN, URSULA MOCEK, BERT STEFFAN, WOLFGANG STEGLICH

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JOURNAL FREE ACCESS

1990 Volume 43 Issue 11 Pages 1413-1420

DOI https://doi.org/10.7164/antibiotics.43.1413

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Abstract

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of ¹⁴C- acetate into cholesterol in HeLa cells while the incorporation of ¹⁴C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

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