ACTIKETAL, A NEW MEMBER OF THE GLUTARIMIDE ANTIBIOTICS
1991 Volume 44 Issue 2 Pages 160-163
Details
1991 Volume 44 Issue 2 Pages 160-163
A new glutarimide antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 μM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-{1H} NOE's techniques.
