The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SPHINGOFUNGINS A, B, C, AND D; A NEW FAMILY OF ANTIFUNGAL AGENTS
I. FERMENTATION, ISOLATION, AND BIOLOGICAL ACTIVITY
FRANK VANMIDDLESWORTH, ROBERT A. GIACOBBE, MARIA LOPEZ, GEORGE GARRITY, JUDITH A. BLAND, KEN BARTIZAL, ROBERT A. FROMTLING, JON POLISHOOK, MARCIA ZWEERINK, ANN M. EDISON, WALTER ROZDILSKY, KENNETH E. WILSON, RICHARD L. MONAGHAN
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1992 Volume 45 Issue 6 Pages 861-867

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Abstract

In screening for antifimgal inhibitors from fungi, four related antifungal agents have been isolated from the cultivation of Aspergillus fumigatus ATCC 20857. These agents were initially produced by the microorganism growing on a solid millet-based medium. A liquid medium containing both glucose and glycerol has also been developed in which these antibiotics are produced in two phases. These novel compounds, sphingofungins A, B, C, and D, show a limited spectrum of antifungal activity but were especially effective against Cryptococcus species.

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The Journal of Antibiotics, Series A

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