The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
HERBOXIDIENE, A NEW HERBICIDAL SUBSTANCE FROM Streptomyces chromofuscus A7847
TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
MARGARET MILLER-WIDEMANNARINDER MAKKARMINHTIEN TRANBARBARA ISAACNANCY BIESTRICHARD STONARD
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1992 Volume 45 Issue 6 Pages 914-921

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Abstract

Screening of microbial fermentation broths for herbicidal activity led to the discovery of a novel polyketide, herboxidiene, from an actinomycete identified as a member of the Streptomyces chromofuscus cluster. A 14- to 20-fold increase in fermentation production of herboxidiene was achieved as a result of media optimization. Herboxidiene was purified using successive reverse phase C18 steps and Sephadex LH-20 chromatography. Its molecular formula, C25H42O6, was determined by HRFAB-MS. Herboxidiene demonstrated exceptionally potent, selective, herbicidal activity against a variety of weed species and was inactive against wheat, even at rates as high as 5.6 kg/hectare.

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© Japan Antibiotics Research Association
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