The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
FUNGAL METABOLITES. Part 12. POTENT IMMUNOSUPPRESSANT, 14-DEOXOMYRIOGIN, (2S, 3R, 4R-(E)2-AMINO-3, 4-DIHYDROXY-2-HYDROXYMETHYLEICOS-6-ENOIC ACID AND STRUCTURE-ACTIVITY RELATIONSHIPS OF MYRIOCIN DERIVATIVES
TETSURO FUJITA, KENICHIRO INOUE, SATOSHI YAMAMOTO, TAKESHI IKUMOTO, SHIGEO SASAKI, RYOUSUKE TOYAMA, KENJI CHIBA, YUKIO HOSHINO, TAKEKI OKUMOTO
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1994 Volume 47 Issue 2 Pages 216-224

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Abstract

In order to investigate the structure-activity relationships, fourteen derivatives of myriocin ((2S', 3R, 4R)-(E)-2-amino-3, 4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid) were prepared and examined for immunosuppressive activity on mouse allogeneic mixed lymphocyte reaction in vitro. Among them, 14-deoxomyriocin ((2S, 3R, 4R)-(E)-2-amino-3, 4-dihydroxy-2-hydroxymethyl-eicos-6-enoic acid) was the most potent. It also suppressed the generation of allo-reactive cytotoxic T lymphocytes in mice upon intraperitoneal administration, with a potency 10-fold greater than that of myriocin.

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The Journal of Antibiotics, Series A

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