MODIFICATION OF GLYCOPEPTIDE ANTIBIOTIC EREMOMYCIN BY THE ACTION OF ALKYL HALIDES AND STUDY ON ANTIBACTERIAL ACTIVITY OF THE COMPOUNDS OBTAINED

A. Y. PAVLOV; E. N. OLSUFYEVA; T. F. BERDNIKOVA; I. V. MALKOVA; M. N. PREOBRAZHENSKAYA; G. D. RISBRIDGER

doi:10.7164/antibiotics.47.225

A. Y. PAVLOV, E. N. OLSUFYEVA, T. F. BERDNIKOVA, I. V. MALKOVA, M. N. PREOBRAZHENSKAYA, G. D. RISBRIDGER

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JOURNAL FREE ACCESS

1994 Volume 47 Issue 2 Pages 225-232

DOI https://doi.org/10.7164/antibiotics.47.225

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Abstract

Alkylation of glycopeptide antibiotic eremomycin by the action of different alkyl halides leads, depending on the structure of alkyl halides used, to eremomycin derivatives of six types; alkylated at the N-terminus, quaternary compounds at the N-terminus, eremomycin esters, esters of eremocycin alkylated at the N-terminus, esters of eremomycin quaternised at the N-terminus, esters of eremomycin alkylated both at the N-terminus and at the aminogroup of disaccharide branch. Five compounds demonstrated high antibacterial activity in vitro, N-allyleremomycin and methyl ester of N, N-dimethyleremomycin being at least as good as the parent eremomycin.

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