Isolation and Structure Elucidation of Five New Asterriquinones from Aspergillus, Humicola and Botryotrichum Species

URSULA MOCEK; LAURI SCHULTZ; TIM BUCHAN; CHARLES BAEK; LARRY FRETTO; JERRY NZEREM; LOUIS SEHL; UMA SINHA

doi:10.7164/antibiotics.49.854

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Isolation and Structure Elucidation of Five New Asterriquinones from Aspergillus, Humicola and Botryotrichum Species

URSULA MOCEK, LAURI SCHULTZ, TIM BUCHAN, CHARLES BAEK, LARRY FRETTO, JERRY NZEREM, LOUIS SEHL, UMA SINHA

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 9 Pages 854-859

DOI https://doi.org/10.7164/antibiotics.49.854

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Abstract

Five new quinone pigments have been discovered from the fermentation broth of Aspergillus, Humicola and Botryotrichum species isolated from different soil samples. These compounds inhibit serine proteases of the coagulation pathway. Their structures which differ in the identity and position of a 5-carbon side chain on the indole moiety have been elucidated based on NMR and FAB-MS experiments.

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