A New Anti-MRSA Antibiotic Complex, WAP-8294A I. Taxonomy, Isolation and Biological Activities

AZUSA KATO; SEIGO NAKAYA; NAOMI KOKUBO; YUJI AIBA; YOSHITAMI OHASHI; HARUHISA HIRATA; KIYONAGA FUJII; KEN-ICHI HARADA

doi:10.7164/antibiotics.51.929

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

A New Anti-MRSA Antibiotic Complex, WAP-8294A

I. Taxonomy, Isolation and Biological Activities

AZUSA KATO, SEIGO NAKAYA, NAOMI KOKUBO, YUJI AIBA, YOSHITAMI OHASHI, HARUHISA HIRATA, KIYONAGA FUJII, KEN-ICHI HARADA

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JOURNAL FREE ACCESS

1998 Volume 51 Issue 10 Pages 929-935

DOI https://doi.org/10.7164/antibiotics.51.929

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Abstract

WAP-8294A, produced by Lysobacter sp., is a complex consisting of water soluble depsipeptide antibiotics. It was further purified by column chromatographies and HPLC, and 19 components were obtained. WAP-8294A2, a major component, and minor components A1, A4, Ax8, Ax9 and Ax13 were active against Gram-positive bacteria, in particular, methicillin-resistant Staphylococcus aureus (MRSA) in vitro. WAP-8294A2 was highly active in vivo in mice against the systemic infection of MRSA.

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