The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Beauveriolides, Specific Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Beauveria sp. FO-6979
ICHIJI NAMATAMEHIROSHI TOMODASHUYI SIYUICHI YAMAGUCHIROKURO MASUMASATOSHI OMURA
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1999 Volume 52 Issue 1 Pages 1-6

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Abstract

Beauveria sp. FO-6979, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. A new compound beauveriolide III was isolated along with a known compound beauveriolide I from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography, silica gel column chromatography and preparative HPLC. Beauveriolides I and III caused a reduction in the number and size of cytosolic lipid droplets in macrophages at 10 μM without any cy to toxic effect on macrophages.

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© Japan Antibiotics Research Association
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