Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus

SHOHEI SAKUDA; MAKOTO ONO; HIROYUKI IKEDA; TAKEFUMI NAKAMURA; YASUHITO INAGAKI; RYU KAWACHI; JIRO NAKAYAMA; AKINORI SUZUKI; AKIRA ISOGAI; HIROMICHI NAGASAWA

doi:10.7164/antibiotics.53.1265

Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus

SHOHEI SAKUDA, MAKOTO ONO, HIROYUKI IKEDA, TAKEFUMI NAKAMURA, YASUHITO INAGAKI, RYU KAWACHI, JIRO NAKAYAMA, AKINORI SUZUKI, AKIRA ISOGAI, HIROMICHI NAGASAWA

Author information

SHOHEI SAKUDA
Department of Applied Biological Chemistry, The University of Tokyo
MAKOTO ONO
Research Institute, Morinaga and Co., Ltd.
HIROYUKI IKEDA
Department of Applied Biological Chemistry, The University of Tokyo
TAKEFUMI NAKAMURA
Department of Applied Biological Chemistry, The University of Tokyo
YASUHITO INAGAKI
Department of Applied Biological Chemistry, The University of Tokyo
RYU KAWACHI
Department of Applied Biological Chemistry, The University of Tokyo
JIRO NAKAYAMA
Department of Applied Biological Chemistry, The University of Tokyo
AKINORI SUZUKI
Department of Applied Biological Chemistry, The University of Tokyo
AKIRA ISOGAI
Graduate School of Biological Sciences, Nara Institute of Science and Technology
HIROMICHI NAGASAWA
Department of Applied Biological Chemistry, The University of Tokyo

JOURNAL FREE ACCESS

2000 Volume 53 Issue 11 Pages 1265-1271

DOI https://doi.org/10.7164/antibiotics.53.1265

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Abstract

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μM.

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