Arylomycins A and B, New Biaryl-bridged Lipopeptide Antibiotics Produced by Streptomyces sp. Tü 6075 I. Taxonomy, Fermentation, Isolation and Biological Activities

JUDITH SCHIMANA; KLAUS GEBHARDT; ALEXANDRA HÖLTZEL; DIETMAR G. SCHMID; RODERICH SÜSSMUTH; JOHANNES MÜLLER; RÜDIGER PUKALL; HANS-PETER FIEDLER

doi:10.7164/antibiotics.55.565

Arylomycins A and B, New Biaryl-bridged Lipopeptide Antibiotics Produced by Streptomyces sp. Tü 6075

I. Taxonomy, Fermentation, Isolation and Biological Activities

JUDITH SCHIMANA, KLAUS GEBHARDT, ALEXANDRA HÖLTZEL, DIETMAR G. SCHMID, RODERICH SÜSSMUTH, JOHANNES MÜLLER, RÜDIGER PUKALL, HANS-PETER FIEDLER

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JOURNAL FREE ACCESS

2002 Volume 55 Issue 6 Pages 565-570

DOI https://doi.org/10.7164/antibiotics.55.565

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Abstract

New lipopeptide antibiotics, colourless arylomycins A series and yellow arylomycins B series were detected in the culture filtrate and mycelium extracts of Streptomyces sp. Tü 6075 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. Arylomycins are a family of lipohexapeptide antibiotics, which represent the first examples of biaryl-bridged lipopeptides. They show antibiotic activities against Gram-positive bacteria.

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