FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919 I. Taxonomy of the Producing Organism, Fermentation, Isolation and Physico-chemical Properties

HIDETAKA HATORI; BUNJI SATO; IKUKO SATO; TOSHIHIRO SHIBATA; YASUHISA TSURUMI; KAZUTOSHI SAKAMOTO; SHIGEHIRO TAKASE; HIROTSUGU UEDA; MOTOHIRO HINO; TAKASHI FUJII

doi:10.7164/antibiotics.57.264

FR901512, a Novel HMG-CoA Reductase Inhibitor Produced by an Agonomycetous Fungus No. 14919

I. Taxonomy of the Producing Organism, Fermentation, Isolation and Physico-chemical Properties

HIDETAKA HATORI, BUNJI SATO, IKUKO SATO, TOSHIHIRO SHIBATA, YASUHISA TSURUMI, KAZUTOSHI SAKAMOTO, SHIGEHIRO TAKASE, HIROTSUGU UEDA, MOTOHIRO HINO, TAKASHI FUJII

Author information

HIDETAKA HATORI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
BUNJI SATO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
IKUKO SATO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TOSHIHIRO SHIBATA
Research Planning, Research Division, Fujisawa Pharmaceutical Co., Ltd.
YASUHISA TSURUMI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KAZUTOSHI SAKAMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SHIGEHIRO TAKASE
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HIROTSUGU UEDA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MOTOHIRO HINO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TAKASHI FUJII
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

2004 Volume 57 Issue 4 Pages 264-270

DOI https://doi.org/10.7164/antibiotics.57.264

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Abstract

Novel compounds FR901512 and FR901516 were isolated from the fermentation broth of agonomycete strain No. 14919. FR901512 and FR901516 possess unique tetralin ring in their structure. These compounds were potent inhibitors of the cholesterol synthesis in human hepatoma cell line Hep G2. FR901512 shows strong 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitory activity with an IC₅₀ value of 0.95nM.

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