GTP, an Inhibitor of Transglutaminases, is Hydrolyzed by Tissue-type Transglutaminase (TGase 2) but not by Epidermal-type Transglutaminase (TGase 3)

Kiyotaka HITOMI; Koji IKURA; Masatoshi MAKI

doi:10.1271/bbb.64.657

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Biochemistry & Molecular Biology Notes

GTP, an Inhibitor of Transglutaminases, is Hydrolyzed by Tissue-type Transglutaminase (TGase 2) but not by Epidermal-type Transglutaminase (TGase 3)

Kiyotaka HITOMI, Koji IKURA, Masatoshi MAKI

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Keywords: transglutaminase, GTP, GTPase, calcium

JOURNAL FREE ACCESS

2000 Volume 64 Issue 3 Pages 657-659

DOI https://doi.org/10.1271/bbb.64.657

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Abstract

Epidermal-type transglutaminase (TGase 3) is devoid of GTPase activity, but its TGase activity is inhibited by GTP as in the case of tissue-type TGase (TGase 2). In addition, the inhibition was not affected by the presence of higher concentrations of Ca ion. These results indicate that GTP interacts with TGase 3 in a manner different from its action on TGase 2.

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