Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

Ling LIN; SiYang NI; LinZhuan WU; YiGuang WANG; YuCheng WANG; PeiZhen TAO; WeiQing HE; XiangJing WANG

doi:10.1271/bbb.110361

Microbiology & Fermentation Technology Notes

Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997

Ling LIN, SiYang NI, LinZhuan WU, YiGuang WANG, YuCheng WANG, PeiZhen TAO, WeiQing HE, XiangJing WANG

Author information

Ling LIN
Northeast Agricultural University
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
SiYang NI
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
LinZhuan WU
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
YiGuang WANG
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
YuCheng WANG
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
PeiZhen TAO
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
WeiQing HE
Key Lab of Biotechnology of Antibiotics, Ministry of Health, Institute of Medicinal Biotechnology, CAMS & PUMC
XiangJing WANG
Northeast Agricultural University

Keywords: biosynthesis, gdmP, geldanamycin, 4,5-dihydro-thiazinogeldanamycin

JOURNAL FREE ACCESS

2011 Volume 75 Issue 10 Pages 2042-2045

DOI https://doi.org/10.1271/bbb.110361

View "Advance Publication" version (October 7, 2011).

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Abstract

Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.

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