Heat Shock Gene Activation by Mutant Actin Is Independent of Myofibril Degeneration in Drosophila Muscle
1991 Volume 109 Issue 5 Pages 670-673
Details
1991 Volume 109 Issue 5 Pages 670-673
Artificially mutagenized Drosophila Act88F actin genes with triple and double mutations were expressed in the indirect flight muscles of transgenic flies. The triple mutant actin, GD245T (Gly-36→Glu, Glu-83→Asp, and Gly-245→Asp), induced heat shock protein (hsp) synthesis without affecting flight ability. On the other hand, the double mutation, GD245D (Gly-36→Glu and Glu-83→Asp), disrupted myofibrils but induced little hsp synthesis. These results demonstrate that myofibril degeneration is not the primary cause of the anomalous heat shock gene activation by mutant actins.
