Effects of the 5-HT2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine (PCA) in Mice

Jun YAMADA; Yumi SUGIMOTO; Minako OHKURA; Kiyo INOUE

doi:10.1248/bpb.24.1195

Notes

Effects of the 5-HT₂ Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine (PCA) in Mice

Jun YAMADA, Yumi SUGIMOTO, Minako OHKURA, Kiyo INOUE

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Keywords: p-chloroamphetamine, hyperthermia, 5-HT₂ receptor, neurotoxicity

JOURNAL FREE ACCESS

2001 Volume 24 Issue 10 Pages 1195-1197

DOI https://doi.org/10.1248/bpb.24.1195

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Abstract

Effects of the 5-HT₂ receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT induced by the 5-HT-releasing drug, p-chloroamphetamine (PCA) were investigated. Ritanserin significantly suppressed PCA-induced hyperthermia in mice. PCA elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by PCA was also attenuated by pretreatment with ritanserin. Since hyperthermia facilitates neurotoxicity induced by amphetamine analogue, ritanserin may inhibit PCA-induced 5-HT neurotoxicity by inhibiting hyperthermia.

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