(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase

Sang Hyun Sung; So Young Kang; Ki Yong Lee; Mi Jung Park; Jeong Hun Kim; Jong Hee Park; Young Chul Kim; Jinwoong Kim; Young Choong Kim

doi:10.1248/bpb.25.125

Notes

(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase

Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim, Young Choong Kim

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Keywords: Caragana chamlague, Leguminosae, AChE inhibitors, (+)-α-viniferin, kobophenol A

JOURNAL FREE ACCESS

2002 Volume 25 Issue 1 Pages 125-127

DOI https://doi.org/10.1248/bpb.25.125

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Abstract

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-α-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC₅₀ values of 1 and 2 were 2.0 and 115.8 µM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

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