Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Tom1 (Target of Myb 1) Is a Novel Negative Regulator of Interleukin-1- and Tumor Necrosis Factor-Induced Signaling Pathways
Megumi YamakamiHideyoshi Yokosawa
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JOURNAL FREE ACCESS

2004 Volume 27 Issue 4 Pages 564-566

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Abstract

The Tom1 (target of Myb 1) protein has VHS and GAT domains in N-terminal and central parts, respectively. The VHS domain has been found in a number of proteins, some of which have been implicated in intracellular trafficking and sorting. We previously showed that Tom1 forms a complex with Tollip, which has been reported to function in interleukin-1 (IL-1)-dependent signaling. In this study, we carried out a reporter gene assay to investigate the function of Tom1 in inflammatory cytokine-dependent signaling. It was found that overexpression of Tom1 suppresses activation of transcription factors, NF-κB and AP-1, induced by either IL-1β or tumor necrosis factor (TNF)-α and that the VHS domain of Tom1 is indispensable for its suppressive activity. Thus, we propose that Tom1 is a common negative regulator of the signaling pathways induced by IL-1β and TNF-α.

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© 2004 The Pharmaceutical Society of Japan
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