Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure

Hiroki Konishi; Masatomo Sudo; Masaki Sumi; Hiroaki Morii; Tokuzo Minouchi; Tachio Aimoto; Akira Yamaji

doi:10.1248/bpb.28.556

Notes

Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure

Hiroki Konishi, Masatomo Sudo, Masaki Sumi, Hiroaki Morii, Tokuzo Minouchi, Tachio Aimoto, Akira Yamaji

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Keywords: micafungin pharmacokinetics, acute hepatic failure rat, carbon tetrachloride, tissue distribution, elimination clearance

JOURNAL FREE ACCESS

2005 Volume 28 Issue 3 Pages 556-559

DOI https://doi.org/10.1248/bpb.28.556

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Abstract

We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl₄) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CL_tot) in CCl₄-treated rats, while the steady-state volume of distribution (Vd_ss) was significantly increased by CCl₄ treatment. Alteration in the serum unbound fraction of micafungin after CCl₄ treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vd_ss was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl₄ treatment.

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