Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Communications to the Editor
Hypoglycemic Effects of Turmeric (Curcuma longa L. Rhizomes) on Genetically Diabetic KK-Ay Mice
Minpei Kuroda, Yoshihiro Mimaki, Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Misuzu Tsukagawa, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara
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Keywords: Curcuma longa L., adipocyte differentiation, curcuminoid, peroxisome proliferator-activated receptor (PPAR)-γ ligand-binding activity, type 2 diabetes mellitus, sesquiterpenoid
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2005 Volume 28 Issue 5 Pages 937-939

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Abstract

The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-Ay mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-γ ligand-binding activity in a GAL4-PPAR-γ chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-γ ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-γ activation.

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© 2005 The Pharmaceutical Society of Japan
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