Antibacterial Activity of Dipropofol and Related Compounds

Masahiro Ogata; Kanae Tutumimoto Sato; Takao Kunikane; Kentaro Oka; Masako Seki; Shiro Urano; Keiichi Hiramatsu; Toyoshige Endo

doi:10.1248/bpb.28.1120

Notes

Antibacterial Activity of Dipropofol and Related Compounds

Masahiro Ogata, Kanae Tutumimoto Sato, Takao Kunikane, Kentaro Oka, Masako Seki, Shiro Urano, Keiichi Hiramatsu, Toyoshige Endo

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Keywords: dipropofol, antimicrobial activity, vancomycin resistant Enterococci (VRE), antioxidant, methicillin resistant Staphylococcus aureus (MRSA)

JOURNAL FREE ACCESS

2005 Volume 28 Issue 6 Pages 1120-1122

DOI https://doi.org/10.1248/bpb.28.1120

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Abstract

Phenolic compounds, in general, exhibit antioxidant and antibacterial activities. We studied antimicrobial activity of the phenolic antioxidants, propofol (2,6-diisopropylphenol), tocopherol, eugenol, butylated hydroxyanisole (BHA), and several of their dimer compounds. Dipropofol (dimer of 2,6-diisopropylphenol) showed strong antibacterial activity against gram-positive strains including methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE), while propofol and other monomeric and dimeric phenols having methyl or tert-butyl groups showed no remarkable activity. The results indicated that the dimeric structure of 2,6-diisopropylphenol moiety may play an important role in the antibacterial activity.

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