The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats

Ok-Sun Choi; Sung-Joo Park; Sang-Wan Seo; Cheung-Seog Park; Jeong-Je Cho; Hyun-Jong Ahn

doi:10.1248/bpb.28.1394

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The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats

Ok-Sun Choi, Sung-Joo Park, Sang-Wan Seo, Cheung-Seog Park, Jeong-Je Cho, Hyun-Jong Ahn

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Keywords: statin, anti-inflammatory effect, acute pancreatitis

JOURNAL FREE ACCESS

2005 Volume 28 Issue 8 Pages 1394-1397

DOI https://doi.org/10.1248/bpb.28.1394

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Abstract

Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas weight/body weight (pw/bw) ratio in CCK-induced acute pancreatitis was significantly lower than DMSO-treated group. Statin also increased the pancreatic level of HSP 60. Additionally, the secretions of IL-1β, TNF-α and IL-6 and the lipase levels were decreased in statin treated group. These results suggest that statin may play an important role in mitigating the progression of the inflammatory reactions during acute pancreatitis.

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