Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia

Hyeon Gyeong Yoo; Jin Sook Kim; Se Rah Lee; Hyun Keol Pyo; Hyung In Moon; Jong Hee Lee; Oh Sang Kwon; Jin Ho Chung; Kyu Han Kim; Hee Chul Eun; Kwang Hyun Cho

doi:10.1248/bpb.29.1246

Notes

Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia

Hyeon Gyeong Yoo, Jin Sook Kim, Se Rah Lee, Hyun Keol Pyo, Hyung In Moon, Jong Hee Lee, Oh Sang Kwon, Jin Ho Chung, Kyu Han Kim, Hee Chul Eun, Kwang Hyun Cho

Author information

Hyeon Gyeong Yoo
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Jin Sook Kim
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Se Rah Lee
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Hyun Keol Pyo
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Hyung In Moon
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Jong Hee Lee
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Oh Sang Kwon
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Jin Ho Chung
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Kyu Han Kim
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Hee Chul Eun
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University
Kwang Hyun Cho
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, and Institute of Dermatological Science, Seoul National University

Keywords: fibrosis, finasteride, androgenetic alopecia, type I procollagen, TGF-β1

JOURNAL FREE ACCESS

2006 Volume 29 Issue 6 Pages 1246-1250

DOI https://doi.org/10.1248/bpb.29.1246

Details

Abstract

Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10⁻⁹—10⁻⁷ M) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10⁻⁸ M) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-β1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-β1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-β1 antibody (10 μg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-β1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-β1 expression may explain another possible mechanism how finasteride works in AGA.

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