A Diterpenoid Acanthoic Acid from Acanthopanax koreanum Protects against <small>D</small>-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

Ji-Xing Nan; Xue-Jun Jin; Li-Hua Lian; Xing Fu Cai; Ying-Zi Jiang; Hong Ri Jin; Jung Joon Lee

doi:10.1248/bpb.31.738

Notes

A Diterpenoid Acanthoic Acid from Acanthopanax koreanum Protects against D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

Ji-Xing Nan, Xue-Jun Jin, Li-Hua Lian, Xing Fu Cai, Ying-Zi Jiang, Hong Ri Jin, Jung Joon Lee

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Keywords: Acanthopanax koreanum, acanthoic acid, fulminant hepatitis, apoptosis, tumor necrosis factor-α

JOURNAL FREE ACCESS

2008 Volume 31 Issue 4 Pages 738-742

DOI https://doi.org/10.1248/bpb.31.738

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Abstract

The hepatoprotective effects of a diterpenoid acanthoic acid isolated from Acanthopanax koreanum NAKAI were evaluated in a D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure mouse model. Mice were pretreated orally with acanthoic acid 12 and 1 h before intraperitoneal injection of D-galactosamine and lipopolysaccharide. Pretreatment with the compound markedly reduced lethal liver injury in experimental animals. The effects were likely associated with a significant decrease in serum tumor necrosis factor (TNF)-α levels, which are correlated not only with those of alanine aminotransferase and aspartate aminotransferase but also with the reduced number of apoptotic hepatocytes in the liver as confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay. These results suggest that acanthoic acid protects against D-galactosamine/lipopolysaccharide-induced fulminant liver failure at least in part by a mechanism associated with the down-regulation of TNF-α secretion.

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