Systematic analysis of 8 artificial sweeteners, namely, saccharin aspartame sucralose acesulfame K neotame cyclamate (CY) dulcin (DU) and alitame, was partially improved. Chopped or homogenized samples were packed into cellulose tubing with 0.01mol/L hydrochloric acid containing 10% sodium chloride, and dialyzed against 0.01mol/L hydrochloric acid for 24-48 hours. The dialyzate was cleaned up using a solid-phase extraction method with an Oasis HLB cartridge for CY and a Sep-Pak Vac C18 cartridge for DU. The average recovery of CY and DU from 9 types of foods spiked with 200μg/g was above 96%. Their detection limits were 5μg/g in samples. Furthermore, CY and DU were both successfully identified by liquid chromatography with tandem mass spectrometry.