Significance of the Level of Monocyte Chemoattractant Protein-1 in Human Atherosclerosis Assessment in Chronic Hemodialysis Patients

Kengo Fukushima Kusano; Kazufumi Nakamura; Hitoshi Kusano; Nobuhiro Nishii; Kimikazu Banba; Tetsuya Ikeda; Katsushi Hashimoto; Mika Yamamoto; Hideki Fujio; Aya Miura; Keiko Ohta; Hiroshi Morita; Hironori Saito; Tetsuro Emori; Yoichi Nakamura; Isao Kusano; Tohru Ohe

doi:10.1253/circj.68.671

Clinical Investigation

Significance of the Level of Monocyte Chemoattractant Protein-1 in Human Atherosclerosis

Assessment in Chronic Hemodialysis Patients

Kengo Fukushima Kusano, Kazufumi Nakamura, Hitoshi Kusano, Nobuhiro Nishii, Kimikazu Banba, Tetsuya Ikeda, Katsushi Hashimoto, Mika Yamamoto, Hideki Fujio, Aya Miura, Keiko Ohta, Hiroshi Morita, Hironori Saito, Tetsuro Emori, Yoichi Nakamura, Isao Kusano, Tohru Ohe

Author information

Kengo Fukushima Kusano
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Kazufumi Nakamura
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Hitoshi Kusano
Fukushima-Naika Clinic
Nobuhiro Nishii
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Kimikazu Banba
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Tetsuya Ikeda
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Katsushi Hashimoto
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Mika Yamamoto
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Hideki Fujio
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Aya Miura
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Keiko Ohta
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Hiroshi Morita
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Hironori Saito
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Tetsuro Emori
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Yoichi Nakamura
Department of Cardiovascular Medicine, Matsuyama Shimin Hospital
Isao Kusano
Fukushima-Naika Clinic
Tohru Ohe
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry

Keywords: Atherosclerosis, Cytokine, Hemodialysis

JOURNAL FREE ACCESS

2004 Volume 68 Issue 7 Pages 671-676

DOI https://doi.org/10.1253/circj.68.671

Details

Abstract

Background Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results The serum MCP-1 concentrations and the intimal - medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients. (Circ J 2004; 68: 671 - 676)

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