Long-Term Prognosis of Dilated Cardiomyopathy Revisited An Improvement in Survival Over the Past 20 Years

Yoshihisa Matsumura; Jun Takata; Hiroaki Kitaoka; Toru Kubo; Yuichi Baba; Eri Hoshikawa; Tomoyuki Hamada; Makoto Okawa; Nobuhiko Hitomi; Kyoko Sato; Naohito Yamasaki; Toshikazu Yabe; Takashi Furuno; Masanori Nishinaga; Yoshinori Doi

doi:10.1253/circj.70.376

Clinical Investigation

Long-Term Prognosis of Dilated Cardiomyopathy Revisited

An Improvement in Survival Over the Past 20 Years

Yoshihisa Matsumura, Jun Takata, Hiroaki Kitaoka, Toru Kubo, Yuichi Baba, Eri Hoshikawa, Tomoyuki Hamada, Makoto Okawa, Nobuhiko Hitomi, Kyoko Sato, Naohito Yamasaki, Toshikazu Yabe, Takashi Furuno, Masanori Nishinaga, Yoshinori Doi

Author information

Yoshihisa Matsumura
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Jun Takata
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Hiroaki Kitaoka
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Toru Kubo
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Yuichi Baba
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Eri Hoshikawa
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Tomoyuki Hamada
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Makoto Okawa
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Nobuhiko Hitomi
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Kyoko Sato
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Naohito Yamasaki
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Toshikazu Yabe
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Takashi Furuno
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Masanori Nishinaga
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
Yoshinori Doi
Department of Medicine and Geriatrics, Kochi Medical School, Kochi University

Keywords: Dilated cardiomyopathy, Prognosis

JOURNAL FREE ACCESS

2006 Volume 70 Issue 4 Pages 376-383

DOI https://doi.org/10.1253/circj.70.376

Details

Abstract

Background Because of their favorable prognostic effects, angiotensin converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB) and β blockers have become background therapy in dilated cardiomyopathy (DCM). However, there are few reports concerning the long-term prognosis of Japanese patients with DCM in relation to these treatments. Methods and Results One hundred and fifty patients with DCM were divided into 2 groups: group A (n=46) (diagnosis: 1982-1989) and group B (n=104) (diagnosis: 1990-2002). During follow-up period of 6.9±4.8 years, 62 patients died and 1 patient had a heart transplant. The survival rate at 5 and 10 years was 60.9% and 34.8%, respectively, in group A patients, and 80.9% and 65.3%, respectively, in group B patients (p=0.0079). In group A patients, ACEI/ARB or β blockers were less frequently used (p<0.0001), whereas antiarrhythmics (class Ia or Ib) were more often used (p<0.0001). The patients treated with ACEI/ARB and β blockers showed a better survival rate than those without (p<0.0001). The patients with antiarrhythmics showed a worse survival rate than those without (p<0.0001). Conclusion The prognosis of Japanese patients with DCM has significantly improved over the past 20 years. This improvement may be explained partly through the increased use of ACEI/ARB and β blockers and a declining use of antiarrhythmics. (Circ J 2006; 70: 376 - 383)

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