Granulocyte Colony-Stimulating Factor A Noninvasive Regeneration Therapy for Treating Atherosclerotic Peripheral Artery Disease

Masazumi Arai; Yu Misao; Hiroshi Nagai; Masanori Kawasaki; Kenshi Nagashima; Koji Suzuki; Kunihiko Tsuchiya; Setsuko Otsuka; Yoshihiro Uno; Genzou Takemura; Kazuhiko Nishigaki; Shinya Minatoguchi; Hisayoshi Fujiwara

doi:10.1253/circj.70.1093

Clinical Investigation

Granulocyte Colony-Stimulating Factor

A Noninvasive Regeneration Therapy for Treating Atherosclerotic Peripheral Artery Disease

Masazumi Arai, Yu Misao, Hiroshi Nagai, Masanori Kawasaki, Kenshi Nagashima, Koji Suzuki, Kunihiko Tsuchiya, Setsuko Otsuka, Yoshihiro Uno, Genzou Takemura, Kazuhiko Nishigaki, Shinya Minatoguchi, Hisayoshi Fujiwara

Author information

Masazumi Arai
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Yu Misao
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Hiroshi Nagai
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Masanori Kawasaki
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Kenshi Nagashima
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Koji Suzuki
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Kunihiko Tsuchiya
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Setsuko Otsuka
Department of Transfusion Medicine, Gifu University Graduate School of Medicine
Yoshihiro Uno
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Genzou Takemura
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Kazuhiko Nishigaki
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Shinya Minatoguchi
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Hisayoshi Fujiwara
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine

Keywords: Angiogenesis, Bone marrow cells, Granulocyte colony-stimulating factor, Limb ischemia

JOURNAL FREE ACCESS

2006 Volume 70 Issue 9 Pages 1093-1098

DOI https://doi.org/10.1253/circj.70.1093

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Abstract

Background The purpose of this study was to determine whether treatment with granulocyte colony-stimulating factor (G-CSF), which mobilizes endothelial progenitor cells from bone marrow, can safely improve the clinical outcomes of patients with atherosclerotic peripheral artery disease (PAD). Methods and Results Thirty-nine patients with intractable PAD were randomly assigned to 3 groups: a negative control group (n=12) treated with conventional drug therapy; a positive control group (n=13) treated with conventional drug therapy plus bone marrow transplantation (BMT); and a G-CSF group (n=14) treated with conventional therapy plus subcutaneous injection of 2-5 μg/kg of recombinant human G-CSF once daily for 10 days. One month after treatment, subjective symptoms improved significantly in the G-CSF and BMT groups. Ankle-brachial pressure index and transcutaneous oxygen pressure increased significantly in the BMT and G-CSF groups, but no such improvements were seen in the group receiving conventional therapy alone. Conclusions G-CSF improves the clinical signs and symptoms of patients with intractable PAD to the same degree as BMT does. This noninvasive treatment may thus represent a useful new approach to managing the disease. (Circ J 2006; 70: 1093 - 1098)

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