Intriguing Peri-Strut Low-Intensity Area Detected by Optical Coherence Tomography After Coronary Stent Deployment

Tomohiko Teramoto; Fumiaki Ikeno; Hiromasa Otake; Jennifer K. Lyons; Heleen M. M. van Beusekom; William F. Fearon; Alan C. Yeung

doi:10.1253/circj.CJ-10-0189

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Intriguing Peri-Strut Low-Intensity Area Detected by Optical Coherence Tomography After Coronary Stent Deployment

Tomohiko Teramoto, Fumiaki Ikeno, Hiromasa Otake, Jennifer K. Lyons, Heleen M. M. van Beusekom, William F. Fearon, Alan C. Yeung

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Keywords: Drug-eluting stent (DES), Optical coherence tomography (OCT), Restenosis

JOURNAL FREE ACCESS

2010 Volume 74 Issue 6 Pages 1257-1259

DOI https://doi.org/10.1253/circj.CJ-10-0189

View "Advance Publication" version (April 29, 2010).

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Abstract

Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting. (Circ J 2010; 74: 1257 - 1259)

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