Circulating CD34+/133+ Progenitor Cells in Patients With Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention

Kenshiro Arao; Takanori Yasu; Nobuhiro Ohmura; Yoshiaki Tsukamoto; Miho Murata; Norifumi Kubo; Tomio Umemoto; Nahoko Ikeda; Junya Ako; San-e Ishikawa; Masanobu Kawakami; Shin-ichi Momomura

doi:10.1253/circj.CJ-09-0917

Ischemic Heart Disease

Circulating CD34⁺/133⁺ Progenitor Cells in Patients With Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention

Kenshiro Arao, Takanori Yasu, Nobuhiro Ohmura, Yoshiaki Tsukamoto, Miho Murata, Norifumi Kubo, Tomio Umemoto, Nahoko Ikeda, Junya Ako, San-e Ishikawa, Masanobu Kawakami, Shin-ichi Momomura

Author information

Kenshiro Arao
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Takanori Yasu
Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Graduate School of Medicine
Nobuhiro Ohmura
Division of Cardiovascular Medicine, Kawasaki Saiwai Hospital
Yoshiaki Tsukamoto
Division of Cardiovascular Medicine, Kawasaki Saiwai Hospital
Miho Murata
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Norifumi Kubo
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Tomio Umemoto
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Nahoko Ikeda
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Junya Ako
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
San-e Ishikawa
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Masanobu Kawakami
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University
Shin-ichi Momomura
First Department of Integrated Medicine Saitama Medical Center, Jichi Medical University

Keywords: Coronary artery disease, Endothelium, Exercise, Percutaneous coronary intervention, Prognosis

JOURNAL FREE ACCESS

2010 Volume 74 Issue 9 Pages 1929-1935

DOI https://doi.org/10.1253/circj.CJ-09-0917

View "Advance Publication" version (July 8, 2010).

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Abstract

Background: This study explored the clinical significance of CD34⁺/133⁺ circulating progenitor cell (CPC) counts in patients with stable angina pectoris (AP) who underwent percutaneous coronary intervention (PCI). Methods and Results: Subjects comprised 52 patients with stable AP requiring PCI and 50 control patients without AP. In the AP group, blood samples were taken before and 20 min and 24 h after PCI to measure CPC counts by fluorescence-activated cell sorter analysis. The baseline number of CPCs was smaller in the AP group than in controls. In the AP group, body mass index (BMI) correlated positively with the baseline number of CPCs and was an independent predictor of CPC count in multivariate regression analysis. Other conventional risk factors, daily exercise activity and statin administration showed no association with CPC count. CPC counts remained unchanged within 24 h after PCI. Conclusions: CPC counts in patients with AP are influenced by BMI, but not by other coronary risk factors. CPC counts remain unchanged within 24 h after PCI. (Circ J 2010; 74: 1929 - 1935)

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