Association of Estimated Glomerular Filtration Rate and Proteinuria With Lipid-Rich Plaque in Coronary Artery Disease

Yusaku Shimbo; Susumu Suzuki; Hideki Ishii; Yohei Shibata; Yosuke Tatami; Shingo Harata; Naohiro Osugi; Tomoyuki Ota; Akihito Tanaka; Kanako Shibata; Toshihiro Mizukoshi; Yoshinari Yasuda; Shoichi Maruyama; Toyoaki Murohara

doi:10.1253/circj.CJ-15-0460

Renal Disease

Association of Estimated Glomerular Filtration Rate and Proteinuria With Lipid-Rich Plaque in Coronary Artery Disease

Yusaku Shimbo, Susumu Suzuki, Hideki Ishii, Yohei Shibata, Yosuke Tatami, Shingo Harata, Naohiro Osugi, Tomoyuki Ota, Akihito Tanaka, Kanako Shibata, Toshihiro Mizukoshi, Yoshinari Yasuda, Shoichi Maruyama, Toyoaki Murohara

Author information

Yusaku Shimbo
Department of Cardiology, Nagoya University Graduate School of Medicine
Susumu Suzuki
Department of Cardiology, Nagoya University Graduate School of Medicine
Hideki Ishii
Department of Cardiology, Nagoya University Graduate School of Medicine
Yohei Shibata
Department of Cardiology, Nagoya University Graduate School of Medicine
Yosuke Tatami
Department of Cardiology, Nagoya University Graduate School of Medicine
Shingo Harata
Department of Cardiology, Nagoya University Graduate School of Medicine
Naohiro Osugi
Department of Cardiology, Nagoya University Graduate School of Medicine
Tomoyuki Ota
Department of Cardiology, Nagoya University Graduate School of Medicine
Akihito Tanaka
Department of Cardiology, Nagoya University Graduate School of Medicine
Kanako Shibata
Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine
Toshihiro Mizukoshi
Department of Nephrology, Nagoya University Graduate School of Medicine
Yoshinari Yasuda
Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine
Department of Nephrology, Nagoya University Graduate School of Medicine
Shoichi Maruyama
Department of Nephrology, Nagoya University Graduate School of Medicine
Toyoaki Murohara
Department of Cardiology, Nagoya University Graduate School of Medicine

Keywords: Coronary artery disease, Integrated backscatter intravascular ultrasound, Lipid-rich plaque, Proteinuria

JOURNAL FREE ACCESS FULL-TEXT HTML

2015 Volume 79 Issue 10 Pages 2263-2270

DOI https://doi.org/10.1253/circj.CJ-15-0460

Editorial (79-10 pp. 2116-2117)

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Abstract

Background:Estimated glomerular filtration rate (eGFR) and proteinuria are both important determinants of the risk of cardiovascular disease and mortality. The aim of the present study was to investigate the independent and combined effects of eGFR and proteinuria on tissue characterization of the coronary plaques of culprit lesions.Methods and Results:Conventional intravascular ultrasound and 3-D integrated backscatter intravascular ultrasound (IB-IVUS) were performed in 555 patients undergoing elective percutaneous coronary intervention. They were divided into 2 groups according to the absence or presence of proteinuria (dipstick result ≥1+). Patients with proteinuria had coronary plaque with significantly greater percentage lipid volume compared with those without (43.6±14.8% vs. 48.6±16.1%, P=0.005). Combined analysis was done using eGFR and absence or presence of proteinuria. Subjects with eGFR 45–59 ml/min/1.73 m²and proteinuria were significantly more likely to have higher percent lipid volume compared with those with eGFR >60 ml/min/1.73 m²without proteinuria. After multivariate adjustment for confounders, the presence of proteinuria proved to be an independent predictor for lipid-rich plaque (OR, 1.85; 95% CI: 1.12–3.06, P=0.016).Conclusions:The addition of proteinuria to eGFR level may be of value in the risk stratification of patients with coronary artery disease. (Circ J 2015; 79: 2263–2270)

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