Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound

Hiromu Yamazaki; Koji Yamaguchi; Takeshi Soeki; Tetsuzo Wakatsuki; Toshiyuki Niki; Yoshio Taketani; Atsunori Kitaoka; Kenya Kusunose; Takayuki Ise; Takeshi Tobiume; Shusuke Yagi; Takashi Iwase; Hirotsugu Yamada; Masataka Sata

doi:10.1253/circj.CJ-15-0019

Imaging

Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound

Hiromu Yamazaki, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Toshiyuki Niki, Yoshio Taketani, Atsunori Kitaoka, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Masataka Sata

Author information

Hiromu Yamazaki
Department of Cardiovascular Medicine, Tokushima University Hospital
Koji Yamaguchi
Department of Cardiovascular Medicine, Tokushima University Hospital
Takeshi Soeki
Department of Cardiovascular Medicine, Tokushima University Hospital
Tetsuzo Wakatsuki
Department of Cardiovascular Medicine, Tokushima University Hospital
Toshiyuki Niki
Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
Yoshio Taketani
Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
Atsunori Kitaoka
Medical Engineering Center, Tokushima University Hospital
Kenya Kusunose
Department of Cardiovascular Medicine, Tokushima University Hospital
Takayuki Ise
Department of Cardiovascular Medicine, Tokushima University Hospital
Takeshi Tobiume
Department of Cardiovascular Medicine, Tokushima University Hospital
Shusuke Yagi
Department of Cardiovascular Medicine, Tokushima University Hospital
Takashi Iwase
Department of Cardiovascular Medicine, Tokushima University Hospital
Hirotsugu Yamada
Department of Cardiovascular Medicine, Tokushima University Hospital
Masataka Sata
Department of Cardiovascular Medicine, Tokushima University Hospital

Keywords: Coronary plaque, Indoxyl sulfate, Integrated backscatter intravascular ultrasound

JOURNAL FREE ACCESS FULL-TEXT HTML

2015 Volume 79 Issue 8 Pages 1773-1779

DOI https://doi.org/10.1253/circj.CJ-15-0019

Editorial (79-8 pp. 1691-1692)

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Abstract

Background:Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS).Methods and Results:IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=–0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=–0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=–0.305, P=0.04) independently of potentially confounding coronary risk factors.Conclusions:Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging. (Circ J 2015; 79: 1773–1779)

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