Megistoquinones I and II, Two Quinoline Alkaloids with Antibacterial Activity from the Bark of Sarcomelicope megistophylla

Nikolas Fokialakis; Prokopios Magiatis; Ioanna Chinou; Sofia Mitaku; François Tillequin

doi:10.1248/cpb.50.413

Notes

Megistoquinones I and II, Two Quinoline Alkaloids with Antibacterial Activity from the Bark of Sarcomelicope megistophylla

Nikolas Fokialakis, Prokopios Magiatis, Ioanna Chinou, Sofia Mitaku, François Tillequin

Author information

Keywords: quinolone, alkaloid, antibacterial, Sarcomelicope megistophylla, Rutaceae

JOURNAL FREE ACCESS

2002 Volume 50 Issue 3 Pages 413-414

DOI https://doi.org/10.1248/cpb.50.413

Details

Abstract

Two alkaloids, megistoquinone I (1) and megistoquinone II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to quinoline alkaloid series and should be considered as oxidation products of a furo[2,3-b]quinoline precursor. The two alkaloids showed antibacterial properties with minimum inhibitory concentration (MIC) ranging from 2.35 to 5.25 mg/ml for 1 and 0.73 to 1.23 mg/ml for 2.

Corresponding author

Register with J-STAGE for free!