Tetracyclic Triterpenoids from the Leaves of Azadirachta indica and Their Insecticidal Activities

Bina Shaheen Siddiqui; Farhana Afshan; Tahsin Gulzar; Razia Sultana; Syed Naeemul-Hassan Naqvi; Rajput Mohammad Tariq

doi:10.1248/cpb.51.415

Notes

Tetracyclic Triterpenoids from the Leaves of Azadirachta indica and Their Insecticidal Activities

Bina Shaheen Siddiqui, Farhana Afshan, Tahsin Gulzar, Razia Sultana, Syed Naeemul-Hassan Naqvi, Rajput Mohammad Tariq

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Keywords: Azadirachta indica, Meliaceae, triterpenoid, Anopheles stephensi

JOURNAL FREE ACCESS

2003 Volume 51 Issue 4 Pages 415-417

DOI https://doi.org/10.1248/cpb.51.415

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Abstract

A new tetranortriterpenoid, meliatetraolenone [24,25,26,27-tetranor-apotirucalla-(apoeupha)-6α-O-methyl, 7α-senecioyl(7-deacetyl)-11α,12α,21,23-tetrahydroxy-21,23-epoxy-2,14,20(22)-trien-1,16-dione] (1) was isolated from the methanolic extract of fresh leaves of Azadirachta indica along with the known compound odoratone (3) which was hitherto unreported from this source. Their structures have been elucidated by spectral studies including 2D NMR. The insecticidal activities of 1 as well as those of odoratone (3) are reported. 1 and odoratone both showed mortality on fourth instar larvae of mosquitoes (Anopheles stephensi) with LC₅₀ values of 16 and 154 ppm, respectively.

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