Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana

Sunit Suksamrarn; Narisara Suwannapoch; Wong Phakhodee; Janthana Thanuhiranlert; Piniti Ratananukul; Nitirat Chimnoi; Apichart Suksamrarn

doi:10.1248/cpb.51.857

Notes

Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana

Sunit Suksamrarn, Narisara Suwannapoch, Wong Phakhodee, Janthana Thanuhiranlert, Piniti Ratananukul, Nitirat Chimnoi, Apichart Suksamrarn

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Keywords: antituberculosis, prenylated xanthone, Garcinia mangostana, Mycobacterium tuberculosis, structure–activity relationship

JOURNAL FREE ACCESS

2003 Volume 51 Issue 7 Pages 857-859

DOI https://doi.org/10.1248/cpb.51.857

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Abstract

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C₅ units or with a C₅ and a modified C₅ groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.

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