Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects

Toshihiro Akihisa; Yosuke Taguchi; Ken Yasukawa; Harukuni Tokuda; Hiroyuki Akazawa; Takashi Suzuki; Yumiko Kimura

doi:10.1248/cpb.54.735

Notes

Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects

Toshihiro Akihisa, Yosuke Taguchi, Ken Yasukawa, Harukuni Tokuda, Hiroyuki Akazawa, Takashi Suzuki, Yumiko Kimura

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Keywords: Acer nikoense, diarylheptanoid, anti-tumor-promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema, Epstein–Barr virus early antigen

JOURNAL FREE ACCESS

2006 Volume 54 Issue 5 Pages 735-739

DOI https://doi.org/10.1248/cpb.54.735

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Abstract

A new cyclic diarylheptanoid, acerogenin M (1), has been isolated along with nine known diarylheptanoids, 2—10, and two known phenolic compounds, 11 and 12, from a MeOH extract of the stem bark of Acer nikoense MAXIM. (Aceraceae). The structure of 1 was determined on the basis of a spectroscopic method. Upon evaluation of the inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice of nine of the compounds (2—6, 8, 10—12), six (2, 4—6, 8, 10) showed a marked anti-inflammatory effect with a 50% inhibitory dose (ID₅₀) of 0.26—0.81 mg per ear. In addition, upon an evaluation against the Epstein–Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, all exhibited moderate inhibitory effects against EBV-EA induction (IC₅₀ values of 356—534 mol ratio/32 pmol TPA).

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