Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Anticancer Constituents from the Roots of Rubia cordifolia L.
Jong Keun Son, Soon Ja Jung, Ji Hyun Jung, Zhe Fang, Chong Soon Lee, Chang Seob Seo, Dong Cheul Moon, Byung Sun Min, Mi Ryeo Kim, Mi Hee Woo
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Keywords: Rubia cordifolia L., epoxymollugin, topoisomerase, cytotoxicity
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2008 Volume 56 Issue 2 Pages 213-216

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Abstract

Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4—9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.

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© 2008 The Pharmaceutical Society of Japan
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