Studies on Bioactive Substances in Crude Drugs Used for Arthritic Diseases in Traditional Chinese Medicine. III. Isolation and Identification of Anti-inflammatory and Analgesic Principles from the Whole Herb of Pyrola rotundifolia L.

TAKUO KOSUGE; MASAMI YOKOTA; KIYOSHI SUGIYAMA; TAKAKI MURE; HIROYO YAMAZAWA; TOSUKE YAMAMOTO

doi:10.1248/cpb.33.5355

TAKUO KOSUGE, MASAMI YOKOTA, KIYOSHI SUGIYAMA, TAKAKI MURE, HIROYO YAMAZAWA, TOSUKE YAMAMOTO

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Keywords: anti-arthritic principle

JOURNAL FREE ACCESS

1985 Volume 33 Issue 12 Pages 5355-5357

DOI https://doi.org/10.1248/cpb.33.5355

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Abstract

Anti-inflammatory and analgesic principles were isolated from the methanol extract of the whole herb of Pyrola rotundifolia L., based on bioassays of the inhibitory activities on carrageenaninduced hind paw edema in rats and on acetic acid-induced writhing in mice. The principles were identified as ursolic acid and chimaphilin.

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