Heterocyclic Quinones. XVI. : Pharmacomodulation in the Series of 11H-Indolo[3, 2-c]quinolinediones : Synthesis, Cytotoxicity and Antitumor Activity of 3-Substituted 11H-Pyrido[3', 4' : 4, 5]pyrrolo[3, 2-c]quinoline-1, 4-diones

Phillippe HELISSEY; Sylviane GIORGI-RENAULT; Jean RENAULT; Suzanne CROS

doi:10.1248/cpb.37.2413

Phillippe HELISSEY, Sylviane GIORGI-RENAULT, Jean RENAULT, Suzanne CROS

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Keywords: antitumor activity, cytotoxicity, Fremy's salt, L1210 leukemia cell, 11H-pyrido[3', 4' : 4, 5]pyrrolo[3, 2-c]quinoline-1, 4-dione, heterocyclic quinone, 7, 8, 9, 10-tetrahydro-11H-pyrido[3', 4' : 4, 5]pyrrolo[3, 2-c]quinoline-1, 4-dione

JOURNAL FREE ACCESS

1989 Volume 37 Issue 9 Pages 2413-2416

DOI https://doi.org/10.1248/cpb.37.2413

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Abstract

With the aim of obtaining new antitumor drugs more active than previously described 11H-indolo[3, 2-c]quinoline-1, 4-diones and 7, 8, 9, 10-tetrahydro-11H-indolo[3, 2-c]quinoline-1, 4-diones, the synthesis and activities of a series of 3-substituted 11H-pyrido[3', 4' : 4, 5]pyrrolo[3, 2-c]quinoline-1, 4-diones and of 7, 8, 9, 10-tetrahydro-11H-pyrido-[3', 4' : 4, 5]pyrrolo[3, 2-c]quinoline-1, 4-diones were studied. Some quinones were more cytotoxic in vitro towards L1210 leukemia cells but were not active in vivo towards murine P388 leukemia.

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